Scientific Overview
Stress and Stress Tolerance
HPA Axis
Circadian Rhythms
Immune System
Placebo Effect
Chronic Fatigue Syndrome
Chronic Pain
Psychiatric vs Organic Debate
Irritable Bowel Syndrome
Chronic Lyme Disease
Recovery from ME/CFS


What causes burnout and chronic fatigue syndrome? is a review of the scientific literature showing how chronic stress — whether through infection, excessive physical training, work, emotional or mental, or (usually) a combination — can result in burnout, overtraining syndrome and chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS), and the relationship between stress load, mental attitude, lifestyle and physical health.

"All in all, I am very impressed with it and rather enjoyed reading it...I think it is great tool for patient education." - Peter DeMauro, M.D., Hackensack University Medical Center
"You have written a clear and well argued article" - Dr. Fiona Godlee, Editor in chief, The BMJ

Based on the latest research into areas such as the HPA axis, this website presents information showing how the brain interacts with the immune system and the body's hormone rhythms via the HPA axis and autonomic nervous system to influence health, vitality and stress tolerance. This site also presents the first-ever cohesive theory to explain burnout, chronic fatigue syndrome (CFS, also known as Myalgic Encephalomyelitis or ME), irritable bowel syndrome (IBS), post-viral fatigue syndrome (PVFS) and other misunderstood illnesses, explaining why these illnesses occur and how they can be treated.

If you're looking for quick information about recovering from CFS/ME, head over to the recovery from CFS/ME/burnout section.

See also the Chronic Fatigue Syndrome: learn how the mind-body method works article we have published at

NEW: we have now published a free video presentation giving an overview of the material:

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DISCLAIMER: is an educational resource for chronic fatigue syndrome (CFS), myalgic encephalomyelitis (ME), burnout and related disorders, and is not giving medical advice. Seek advice from a medical practitioner before making any changes to your life, or if you experience worsening symptoms. CFS is a diagnosis of exclusion, so it is important to rule out other causes for illness.